![]() ![]() To determine if such a pathway exists in drug anaphylaxis, we conducted a multicentric study on patients with suspected anaphylaxis to neuromuscular blocking agents (NMBA) during general anesthesia. ![]() Evidence of this mechanism in human is scarce and limited to rare allergens of high molecular weight such as dextran or protamine. ![]() However, data from animal models suggest an alternative pathway dependent on IgG antibodies and involving platelet-activating factor (PAF) release by monocyte/macrophages and neutrophils. 1APHP, Hôpital Bichat, UF Auto-immunité et Hypersensibilités, HUPNVS, Paris, France 2Institut Pasteur, Department of Immunology, Unit of Antibodies in Therapy and Pathology, Paris, France 3APHP, Hôpital Bichat, Department of Epidemiology and Clinical Research, INSERM, Paris, France 4Institut Pasteur, Département Biologie Structurale et Chimie, Unité de Chimie des Biomolécules, Paris, France 5Hôpital Foch, Service de médecine interne, Suresnes, France 6APHP, Hôpital Bichat, Service de Pneumologie A, HUPNVS, Paris, France 7INSERM, ECEVE, U1123, CIC 1421, Paris, France 8APHP, Hôpital Bichat, Département d’Anesthésie-Réanimation, HUPNVS, Paris, FranceĬorrespondence: Luc De Chaisemartin - and Translational Allergy 2018, 8(Suppl 3):O01Īnaphylaxis is an acute systemic hypersensitivity reaction considered to rely on IgE antibodies against an allergen and histamine release by mast cells and basophils. ![]()
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